BDBM305731 6-(2-hydroxy-2- methylpropoxy)-4-(6-(4- hydroxy-4-(2- methylbenzyl)piperidin- 1-yl)pyridin-3-yl) pyrazolo[1,5-a]pyridine- 3-carbonitrile::US10144734, Example 749::US10172845, Example 749::US10441581, Example 749::US10881652, Example 749::US11648243, Example 749

SMILES Cc1ccccc1CC1(O)CCN(CC1)c1ccc(cn1)-c1cc(OCC(C)(C)O)cn2ncc(C#N)c12

InChI Key InChIKey=RHBYWJHTRNGCNZ-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 305731   

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM305731(6-(2-hydroxy-2- methylpropoxy)-4-(6-(4- hydroxy-4-...)
Affinity DataIC50:  2.58E+3nMAssay Description:The potency of a compound inhibiting G810R mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays contained...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM305731(6-(2-hydroxy-2- methylpropoxy)-4-(6-(4- hydroxy-4-...)
Affinity DataIC50:  2.58E+3nMAssay Description:The potency of a compound inhibiting G81 OR mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays containe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM305731(6-(2-hydroxy-2- methylpropoxy)-4-(6-(4- hydroxy-4-...)
Affinity DataIC50:  2.58E+3nMAssay Description:The potency of a compound inhibiting G810R mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays contained...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM305731(6-(2-hydroxy-2- methylpropoxy)-4-(6-(4- hydroxy-4-...)
Affinity DataIC50:  152nMAssay Description:The potency of a compound inhibiting G810R mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays contained...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM305731(6-(2-hydroxy-2- methylpropoxy)-4-(6-(4- hydroxy-4-...)
Affinity DataIC50:  2.58E+3nMAssay Description:The potency of a compound inhibiting G81 OR mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays containe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent